Anti scelorotic Effect of Hydroalcoholic Extract of verbascum thapsus, Lemon Peel and Juice and Quinacrine on Blood Lipids, C-Reactive Protein and Phospholipase A2 Activity in Male Wistar Rats

Introduction: Atherosclerosis is a disease of the veins characterized by the deposition of low-density lipoprotein (LDL) cholesterol and total cholesterol on the inner wall of medium and large diameter arteries. The aim of this study was to compare the anti-sclerotic effect of hydroalcoholic extract of verbascum Thapsus, lemon juice, lemon peel and quinacrine on blood lipid concentration, C-reactive protein (CRP) and phospholipase A2 (PLA2) enzyme activity in male Wistar rats. Materials and Methods: In this study, 25 male wistar rats were randomly divided into the control (n=5) and high fat diet groups (n=20). After 2 months of a high fat diet, rats with hypercholesterolemia were divided into 4 groups: receiving 2.5 ml/kg body weight lemon juice, 500 mg/kg body weight, lemon peel, 800 mg/kg body weight hydroalcoholic extract of verbascum thapsus and 6 mg/kg body weight Quinacrine and treated for one month. Finally, the effects of the drug and extracts on lipid profiles, PLA2 and CRP were evaluated in hypercholesterolemic rats. Results: The high-fat diet increased triglycerides, total cholesterol, and LDL levels and decreased high-density lipoprotein. Administration of hydroalcoholic extract of verbascum thapsus, lemon peel and juiceand quinacrine improved lipid status and decreased phospholipaseA2, CRP activity (P<0.05). Conclusion: Treatment with hydroalcoholic extract of verbascum thapsus, lemon peel and juice and quinacrine can improve lipid concentrations, CRP and phospholipaseA2 activity.